Hydrochloric Acid → HCID 22135614, compound

HRID 1827182Notes

Reaction equation

HRID 1827182 reaction equation
C(OC(=O)[NH:7][CH2:8][CH:9]1[CH2:14][CH2:13][N:12]([S:15]([CH2:18][CH2:19][C:20]2[CH:25]=[CH:24][C:23]([F:26])=[CH:22][CH:21]=2)(=[O:17])=[O:16])[CH2:11][CH2:10]1)(C)(C)C.Cl>O1CCOCC1.C(Cl)(Cl)Cl>[F:26][C:23]1[CH:24]=[CH:25][C:20]([CH2:19][CH2:18][S:15]([N:12]2[CH2:11][CH2:10][CH:9]([CH2:8][NH2:7])[CH2:14][CH2:13]2)(=[O:16])=[O:17])=[CH:21][CH:22]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 23577320HCID 23577320, compound

Product 1

HCID 22135614HCID 22135614, compound

Reagents, catalysts & solvents 2

HCID 6212ChloroformSolventHCID 312751,4-DioxaneSolvent

Procedure

A mixture of 0.4 g of {1-[2-(4-fluoro-phenyl)-ethanesulfonyl]-piperidin-4-ylmethyl}-carbamic acid tert-butyl ester and 5 mL of 4N HCl in dioxane was stirred at room temperature for 3 h, then diluted with 50 mL of chloroform, washed with 50 mL of saturated sodium carbonate, dried over magnesium sulfate and concentrated to dryness under reduced pressure. The product was a white solid:

Workup

  1. washwashed with 50 mL of saturated sodium carbonate
  2. dry with materialdried over magnesium sulfate
  3. concentrationconcentrated to dryness under reduced pressure

Sources & evidence

ORD record
ord-bf3171b0be3f42acbd1f743054507e82
Source dataset
uspto-grants-2006_05
Patent number
US07053089B2

Reaction notes

Loading…