HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromopyrimidine → HCID 9969927, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromopyrimidine | HCID 78345 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | HCID 22135614 | HCID 22135614 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | HCID 9969927 | HCID 9969927 | — |
Reaction Steps
A mixture of 0.3 g of C-{1-[2-(4-Fluoro-phenyl)-ethanesulfonyl]-piperidin-4-yl}-methylamine, 0.3 g of 2-bromopyrimidine, 25 mL of 2-propanol and 0.3 mL of N,N-diisopropylethylamine was heated to reflux overnight. Purification of the residue obtained after concentration under reduced pressure by preparative chromatography, eluting with ethyl acetate gave a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07053089B2 |
| Source dataset | uspto-grants-2006_05 |
| ORD ID | ord-6ef012d8f32740ea8b2aeb52e8ebf84b |
| Source note | uspto-grants-2006_05 |