2-Bromopyrimidine → HCID 9969927, compound

HRID 1827183Notes

Reaction equation

HRID 1827183 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][S:10]([N:13]2[CH2:18][CH2:17][CH:16]([CH2:19][NH2:20])[CH2:15][CH2:14]2)(=[O:12])=[O:11])=[CH:4][CH:3]=1.Br[C:22]1[N:27]=[CH:26][CH:25]=[CH:24][N:23]=1.C(N(CC)C(C)C)(C)C>CC(O)C>[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][S:10]([N:13]2[CH2:14][CH2:15][CH:16]([CH2:19][NH:20][C:22]3[N:27]=[CH:26][CH:25]=[CH:24][N:23]=3)[CH2:17][CH2:18]2)(=[O:11])=[O:12])=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 783452-BromopyrimidineHCID 81531DiisopropylethylamineHCID 22135614HCID 22135614, compound

Product 1

HCID 9969927HCID 9969927, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

A mixture of 0.3 g of C-{1-[2-(4-Fluoro-phenyl)-ethanesulfonyl]-piperidin-4-yl}-methylamine, 0.3 g of 2-bromopyrimidine, 25 mL of 2-propanol and 0.3 mL of N,N-diisopropylethylamine was heated to reflux overnight. Purification of the residue obtained after concentration under reduced pressure by preparative chromatography, eluting with ethyl acetate gave a white solid.

Workup

  1. temperaturewas heated
  2. temperatureto reflux overnight
  3. customPurification of the residue
  4. customobtained
  5. concentrationafter concentration under reduced pressure by preparative chromatography
  6. washeluting with ethyl acetate
  7. customgave a white solid

Sources & evidence

ORD record
ord-6ef012d8f32740ea8b2aeb52e8ebf84b
Source dataset
uspto-grants-2006_05
Patent number
US07053089B2

Reaction notes

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