HCID 23577242, compound → (5-Methyl-pyrimidin-4-yl)-[1-(2-phenyl-ethanesulfonyl)-piperidin-4-ylmethyl]-amine

HRID 1827200Notes

Reaction equation

HRID 1827200 reaction equation
Cl[C:2]1[N:7]=[C:6]([NH:8][CH2:9][CH:10]2[CH2:15][CH2:14][N:13]([S:16]([CH2:19][CH2:20][C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)(=[O:18])=[O:17])[CH2:12][CH2:11]2)[C:5]([CH3:27])=[CH:4][N:3]=1.[H][H]>C(O)C.C(N(CC)CC)C.[Pd]>[CH3:27][C:5]1[C:6]([NH:8][CH2:9][CH:10]2[CH2:11][CH2:12][N:13]([S:16]([CH2:19][CH2:20][C:21]3[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=3)(=[O:17])=[O:18])[CH2:14][CH2:15]2)=[N:7][CH:2]=[N:3][CH:4]=1

Participants

5

Reactant 2

HCID 23577242HCID 23577242, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 23577256(5-Methyl-pyrimidin-4-yl)-[1-(2-phenyl-ethanesulfonyl)-piperidin-4-ylmethyl]-amine

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 22663003EtOH triethylamineSolvent

Procedure

EXAMPLE 92 was prepared from (2-chloro-5-methyl-pyrimidin-4-yl)-[1-(2-phenyl-ethanesulfonyl)-piperidin-4-ylmethyl]-amine by hydrogenation in ethanol-triethylamine over 5% palladium on carbon, 1 atm of hydrogen: MS (m+1)=375.5.

Sources & evidence

ORD record
ord-f810b440943a4ee8be4db80353bb3f77
Source dataset
uspto-grants-2006_05
Patent number
US07053089B2

Reaction notes

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