2-Chloro-4-aminopyrimidine → HCID 23577296, compound

HRID 1827204Notes

Reaction equation

HRID 1827204 reaction equation
[C:1]1([CH2:7][CH2:8][S:9]([N:12]2[CH2:17][CH2:16][CH:15]([CH2:18][NH2:19])[CH2:14][CH2:13]2)(=[O:11])=[O:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl[C:21]1[N:26]=[C:25]([NH2:27])[CH:24]=[CH:23][N:22]=1>>[C:1]1([CH2:7][CH2:8][S:9]([N:12]2[CH2:13][CH2:14][CH:15]([CH2:18][NH:19][C:21]3[N:26]=[C:25]([NH2:27])[CH:24]=[CH:23][N:22]=3)[CH2:16][CH2:17]2)(=[O:10])=[O:11])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

3

Reactant 2

HCID 3457522-Chloro-4-aminopyrimidineHCID 22135729[1-(2-Phenylethylsulfonyl)piperidin-4-yl]methanamine

Product 1

HCID 23577296HCID 23577296, compound

Procedure

EXAMPLE 96 was prepared from C-[1-(2-phenyl-ethanesulfonyl)-piperidin-4-yl]-methylamine and 2-chloro-pyrimidin-4-ylamine (prepared from 2,4-chloro-pyrimidin-4-ylamine by hydrogenation in ethanol over 5% palladium on carbon, 1 atm of hydrogen): MS (m+1)=376.5.

Sources & evidence

ORD record
ord-c8717dbc633e419a979d28abced4d5db
Source dataset
uspto-grants-2006_05
Patent number
US07053089B2

Reaction notes

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