Trifluoroacetic acid → HCID 17966353, compound

HRID 1827236Notes

Reaction equation

HRID 1827236 reaction equation
[CH3:1][C:2]1[S:6][C:5]([CH:7]2[CH2:9][CH:8]2[C:10]([O:12]C(C)(C)C)=[O:11])=[CH:4][CH:3]=1.FC(F)(F)C(O)=O>C(Cl)Cl>[CH3:1][C:2]1[S:6][C:5]([CH:7]2[CH2:9][CH:8]2[C:10]([OH:12])=[O:11])=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 22135673HCID 22135673, compound

Product 1

HCID 17966353HCID 17966353, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of tert-butyl 2-(5-methylthien-2-yl)cyclopropanecarboxylate (100 mg, 0.42 mmol) in CH2Cl2 (3 mL) at RT was added trifluoroacetic acid (1 mL). The reaction mixture was stirred at RT for 10 min and concentrated in vacuo. The crude 2-(5-methylthien-2-yl)cyclopropanecarboxylic acid was used without further purification. M.S. (M+1) 182

Workup

  1. concentrationconcentrated in vacuo
  2. customThe crude 2-(5-methylthien-2-yl)cyclopropanecarboxylic acid was used without further purification

Sources & evidence

ORD record
ord-5b433e92c4774d378f70bdcb8fb52123
Source dataset
uspto-grants-2006_05
Patent number
US07053089B2

Reaction notes

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