反应详情
EQUATION
反应方程式
REACTANTS
反应物
PRODUCTS
生成物
AUXILIARIES
试剂、催化剂与溶剂
PROCEDURE
实验过程
A mixture of (±)-2-amino-4-(3-chlorophenyl)-α-(4-chlorophenyl)-α-(1-methyl-1H-imidazol-5-yl)-6-quinolinemethanol (0.000210 mol) (see Example B8), 4-bromo-benzoic acid (0.000252 mol), N′-(ethylcarbonimidoyl)-N,N-dimethyl-1,3-propanediamine monohydrochloride (0.000315 mol), 1-hydroxy-1H-benzotriazole (0.000315 mol; 1.5 equiv) and Et3N (0.000315 mol) in THF (2 ml) was stirred for 18 hours at room temperature, then taken up into EtOAc and H2O. The organic layer was separated and the solvent evaporated. The residue was purified by HPLC. The product fractions were collected and the solvent was evaporated, yielding 0.065 g (41%) of (±)-4-bromo-N-[4-(3-chlorophenyl)-6-[(4-chlorophenyl)hydroxy(1-methyl-1H-imidazol-5-yl)methyl]-2-quinolinyl]benzamide, MS (ESI) m/z: 657 659 661 663.
WORKUP
后处理
- customThe organic layer was separated
- customthe solvent evaporated
- customThe residue was purified by HPLC
- customThe product fractions were collected
- customthe solvent was evaporated