Sulfuric Acid → HCID 2953193, compound

HRID 1827310Notes

Reaction equation

HRID 1827310 reaction equation
[C:1]([CH:9]([NH:11][C:12](=[O:22])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[NH:19][CH:20]=O)[CH3:10])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.S(=O)(=O)(O)O>CN1CCCC1=O>[C:2]1([C:1](=[O:8])[CH:9]([N:11]2[C:12](=[O:22])[C:13]3[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=3)[N:19]=[CH:20]2)[CH3:10])[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 1118Sulfuric AcidHCID 22137673HCID 22137673, compound

Product 1

HCID 2953193HCID 2953193, compound

Reagents, catalysts & solvents 1

HCID 13387N-methyl-2-pyrrolidoneSolvent

Procedure

A mixture of N-(1-benzoylethyl)-2-(formylamino)-benzamide in N-methyl-pyrrolidone (“NMP”) is dehydrated with concentrated sulfuric acid, cyclizing to provide 3-(1-phenyl-1-oxoprop-2-yl)-quinazolin-4-one.

Sources & evidence

ORD record
ord-ed0ebb716cc24fbcb3d1224ab9c1844f
Source dataset
uspto-grants-2006_05
Patent number
US07053216B2

Reaction notes

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