Cyanoacetic acid → HCID 22137932, compound

HRID 1827364Notes

Reaction equation

HRID 1827364 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:14]=[CH:15][CH:16]=1)[CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([NH2:13])=[CH:9][CH:8]=1.[C:17]([CH2:19][C:20](O)=[O:21])#[N:18]>>[C:17]([CH2:19][C:20]([NH:13][C:10]1[CH:11]=[CH:12][C:7]([O:6][CH2:5][C:4]2[CH:14]=[CH:15][CH:16]=[C:2]([F:1])[CH:3]=2)=[CH:8][CH:9]=1)=[O:21])#[N:18]

Participants

3

Reactant 2

HCID 9740Cyanoacetic acidHCID 167753144-(3-Fluoro-benzyloxy)-phenylamine

Product 1

HCID 22137932HCID 22137932, compound

Procedure

The title compound is prepared in analogy to example 2, starting from 4-(3-fluoro-benzyloxy)-phenylamine (prepared as in example 1b) and cyanoacetic acid. Yield after recrystallisation from methanol: 50%. Colorless crystals with mp=164-166° C.

Workup

  1. customYield
  2. customafter recrystallisation from methanol

Sources & evidence

ORD record
ord-abf10a1e12b94721b88217ad62103ddd
Source dataset
uspto-grants-2006_05
Patent number
US07053245B2

Reaction notes

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