1-Fluoro-4-[(4-nitrophenoxy)methyl]benzene → 4-(4-Fluoro-benzyloxy)-phenylamine

HRID 1827374Notes

Reaction equation

HRID 1827374 reaction equation
FC1C=C(C=CC=1)COC1C=CC(N)=CC=1.[F:17][C:18]1[CH:34]=[CH:33][C:21]([CH2:22][O:23][C:24]2[CH:29]=[CH:28][C:27]([N+:30]([O-])=O)=[CH:26][CH:25]=2)=[CH:20][CH:19]=1>>[F:17][C:18]1[CH:34]=[CH:33][C:21]([CH2:22][O:23][C:24]2[CH:29]=[CH:28][C:27]([NH2:30])=[CH:26][CH:25]=2)=[CH:20][CH:19]=1

Participants

3

Reactant 2

HCID 9575111-Fluoro-4-[(4-nitrophenoxy)methyl]benzeneHCID 167753144-(3-Fluoro-benzyloxy)-phenylamine

Product 1

HCID 64860214-(4-Fluoro-benzyloxy)-phenylamineYield 100%

Procedure

Prepared in analogy to 4-(3-fluoro-benzyloxy)-phenylamine, by hydrogenation of 4-(4-fluoro-benzyloxy)-nitrobenzene. Yield: 100% of a slightly red solid. MS: m/e=218.2 (M++H).

Sources & evidence

ORD record
ord-e361d08a8dcb474f8c761cfcb8e7ab64
Source dataset
uspto-grants-2006_05
Patent number
US07053245B2

Reaction notes

Loading…