Ammonium Hydroxide → N-[4-(4-Fluoro-benzyloxy)-phenyl]-malonamide

HRID 1827376Notes

Reaction equation

HRID 1827376 reaction equation
C[O:2][C:3](=O)[CH2:4][C:5]([NH:7][C:8]1[CH:13]=[CH:12][C:11]([O:14][CH2:15][C:16]2[CH:21]=[CH:20][C:19]([F:22])=[CH:18][CH:17]=2)=[CH:10][CH:9]=1)=[O:6].[OH-].[NH4+:25]>>[F:22][C:19]1[CH:20]=[CH:21][C:16]([CH2:15][O:14][C:11]2[CH:12]=[CH:13][C:8]([NH:7][C:5](=[O:6])[CH2:4][C:3]([NH2:25])=[O:2])=[CH:9][CH:10]=2)=[CH:17][CH:18]=1

Participants

3

Reactant 2

HCID 14923Ammonium HydroxideHCID 10335957N-[4-(4-Fluoro-benzyloxy)-phenyl]-malonamic Acid Methyl Ester

Product 1

HCID 11722432N-[4-(4-Fluoro-benzyloxy)-phenyl]-malonamideYield 80%

Procedure

The title compound is prepared in analogy to example 3 from N-[4-(4-fluoro-benzyloxy)-phenyl]-malonamic acid methyl ester and ammonium hydroxide. Yield: 80%. Colorless solid. MS: m/e=303.2 (M++H).

Sources & evidence

ORD record
ord-bdbe41e3c0ab46288677d4aa34d9cedc
Source dataset
uspto-grants-2006_05
Patent number
US07053245B2

Reaction notes

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