Nitro-4-(3-fluoro-phenoxymethyl)-benzene → 4-(3-Fluoro-phenoxymethyl)-phenylamine

HRID 1827386Notes

Reaction equation

HRID 1827386 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([CH2:10][O:11][C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([F:18])[CH:13]=2)=[CH:6][CH:5]=1)([O-])=O>CO.[Pt]>[F:18][C:14]1[CH:13]=[C:12]([CH:17]=[CH:16][CH:15]=1)[O:11][CH2:10][C:7]1[CH:6]=[CH:5][C:4]([NH2:1])=[CH:9][CH:8]=1

Participants

4

Reactant 1

HCID 22137955Nitro-4-(3-fluoro-phenoxymethyl)-benzene

Product 1

HCID 167938064-(3-Fluoro-phenoxymethyl)-phenylamineYield 112.8%

Reagents, catalysts & solvents 2

HCID 23939PlatinumCatalystHCID 887MethanolSolvent

Procedure

g (4 mmol) of 1-Nitro-4-(3-fluoro-phenoxymethyl)-benzene in 40 ml methanol is treated with 0.25 g of 5% platinum on charcoal and hydrogenated for 1 h at room temperature and normal pressure. The catalyst is filtered and the solution evaporated to yield 0.98 g of the crude title compound as yellow oil. MS: m/e=218.3 (M++H).

Workup

  1. filtrationThe catalyst is filtered
  2. customthe solution evaporated

Sources & evidence

ORD record
ord-e98f04ef2f194a63ad001a25b639b2ca
Source dataset
uspto-grants-2006_05
Patent number
US07053245B2

Reaction notes

Loading…