1-(Aminocarbonyl)-1-cyclopropanecarboxylic acid → Cyclopropane-1,1-dicarboxylic acid amide [4-(3-fluoro-phenoxymethyl)-phenyl]-amide

HRID 1827389Notes

Reaction equation

HRID 1827389 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:14]=[CH:15][CH:16]=1)[O:5][CH2:6][C:7]1[CH:12]=[CH:11][C:10]([NH2:13])=[CH:9][CH:8]=1.[NH2:17][C:18]([C:20]1([C:23](O)=[O:24])[CH2:22][CH2:21]1)=[O:19]>>[F:1][C:2]1[CH:3]=[C:4]([CH:14]=[CH:15][CH:16]=1)[O:5][CH2:6][C:7]1[CH:8]=[CH:9][C:10]([NH:13][C:23]([C:20]2([C:18]([NH2:17])=[O:19])[CH2:22][CH2:21]2)=[O:24])=[CH:11][CH:12]=1

Participants

3

Reactant 2

HCID 27332721-(Aminocarbonyl)-1-cyclopropanecarboxylic acidHCID 167938064-(3-Fluoro-phenoxymethyl)-phenylamine

Product 1

HCID 131724507Cyclopropane-1,1-dicarboxylic acid amide [4-(3-fluoro-phenoxymethyl)-phenyl]-amideYield 42%

Procedure

The title compound is prepared in analogy to example 2 from 4-(3-Fluoro-phenoxymethyl)-phenylamine and 1-(aminocarbonyl)-1-cyclopropane-carboxylic acid. Yield=42%. Colorless solid. MS: m/e=329.3 (M++H).

Sources & evidence

ORD record
ord-0497a65e14d24afba27b753ef36f789b
Source dataset
uspto-grants-2006_05
Patent number
US07053245B2

Reaction notes

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