Ammonium Hydroxide → HCID 9972137, compound

HRID 1827404Notes

Reaction equation

HRID 1827404 reaction equation
C[O:2][C:3](=O)[CH2:4][C:5]([NH:7][C:8]1[CH:13]=[CH:12][C:11]([O:14][CH2:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=2[F:22])=[CH:10][CH:9]=1)=[O:6].[OH-].[NH4+:25]>>[F:22][C:17]1[CH:18]=[CH:19][CH:20]=[CH:21][C:16]=1[CH2:15][O:14][C:11]1[CH:12]=[CH:13][C:8]([NH:7][C:5](=[O:6])[CH2:4][C:3]([NH2:25])=[O:2])=[CH:9][CH:10]=1

Participants

3

Reactant 2

HCID 14923Ammonium HydroxideHCID 10018710HCID 10018710, compound

Product 1

HCID 9972137HCID 9972137, compoundYield 30%

Procedure

Prepared in analogy to example 3 from N-[4-(2-fluoro-benzyloxy)-phenyl]-malonamic acid methyl ester and ammonium hydroxide. Yield=30%. Colorless solid. MS: m/e=303.2 (M++H).

Sources & evidence

ORD record
ord-449c0a357a7c49d6a7f3cd95abd85023
Source dataset
uspto-grants-2006_05
Patent number
US07053245B2

Reaction notes

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