Ammonium Hydroxide → HCID 22137966, compound

HRID 1827406Notes

Reaction equation

HRID 1827406 reaction equation
C[O:2][C:3](=O)[CH2:4][C:5]([NH:7][C:8]1[CH:13]=[CH:12][C:11]([O:14][CH:15]([C:17]2[CH:22]=[CH:21][CH:20]=[C:19]([F:23])[CH:18]=2)[CH3:16])=[CH:10][CH:9]=1)=[O:6].[OH-].[NH4+:26]>>[F:23][C:19]1[CH:18]=[C:17]([CH:15]([O:14][C:11]2[CH:12]=[CH:13][C:8]([NH:7][C:5](=[O:6])[CH2:4][C:3]([NH2:26])=[O:2])=[CH:9][CH:10]=2)[CH3:16])[CH:22]=[CH:21][CH:20]=1

Participants

3

Reactant 2

HCID 14923Ammonium HydroxideHCID 69007046HCID 69007046, compound

Product 1

HCID 22137966HCID 22137966, compoundYield 55%

Procedure

Prepared in analogy to example 3 from N-{4-[1-(3-fluoro-phenyl)-ethoxy]-phenyl}-malonamic acid methyl ester and ammonium hydroxide. Yield=55%. Colorless solid. MS: m/e=317.3 (M++H).

Sources & evidence

ORD record
ord-59cae75a4bbf4ab7baa2020a900cb338
Source dataset
uspto-grants-2006_05
Patent number
US07053245B2

Reaction notes

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