HCID 202244, compound → HCID 13135811, compound

HRID 1827433Notes

Reaction equation

HRID 1827433 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]=[CH:9][C:10]2[CH:15]=[CH:14][C:13]([NH2:16])=[CH:12][CH:11]=2)=[CH:4][CH:3]=1>O1CCCC1.[Pd]>[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:8][CH2:9][C:10]2[CH:11]=[CH:12][C:13]([NH2:16])=[CH:14][CH:15]=2)=[CH:6][CH:7]=1

Participants

4

Reactant 1

HCID 202244HCID 202244, compound

Product 1

HCID 13135811HCID 13135811, compoundYield 99.1%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8028TetrahydrofuranSolvent

Procedure

3.46 g of 4-[2-(4-fluoro-phenyl)-vinyl]-phenylamine is dissolved in 100 ml of tetrahydrofuran, treated with 350 mg of palladium 10% on charcoal and hydrogenated at room temperature and normal pressure for about 4 h. The catalyst is filtered off and the filtrate concentrated to yield 3.46 g (99%) of a yellow solid. MS: m/e=216.9 (M++H).

Workup

  1. filtrationThe catalyst is filtered off
  2. concentrationthe filtrate concentrated

Sources & evidence

ORD record
ord-dc563ef7b2934bf993366703aedebf4f
Source dataset
uspto-grants-2006_05
Patent number
US07053245B2

Reaction notes

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