反应详情

To a solution of 2-{3-[2-(5-Ethyl-pyridin-2-yl)-vinyl]-1H-indazol-6-ylamino}-benzoic acid methyl ester (50 mg, 0.104 mmol) in methanol (0.42 mL) and THF (0.10 mL) was added a solution of sodium hydroxide (12 mg, 0.311 mmol) in water (0.05 mL). The solution was heated to 60 degrees Celsius for 3.5 hours and then neutralized with saturated NH4Cl. The reaction was diluted with water (20 mL), and then extracted with EtOAc (2×20 mL). The combined extracts were first dried over Na2SO4, and then the solids were removed by filtration. The desired product (48.7 mg, 100%) was recovered after rotary evaporation to remove the solvents.

1. temperatureThe solution was heated to 60 degrees Celsius for 3.5 hours
2. extractionextracted with EtOAc (2×20 mL)
3. dry with materialThe combined extracts were first dried over Na2SO4
4. customthe solids were removed by filtration
5. customThe desired product (48.7 mg, 100%) was recovered
6. customafter rotary evaporation
7. customto remove the solvents