反应详情

A mixture of 5-6 (45 g, 110 mmol) and a saturated solution of methylamine in methanol (300 mL) in a sealed tube was heated at 70° C. for 12 hours. The mixture was cooled and concentrated to an oil. The residue was chromatographed on silica gel (10:10:1:1 EtOAc/EtOH/NH4OH/H2O) to give 5-7 as a yellow oil.

1. temperatureThe mixture was cooled
2. concentrationconcentrated to an oil
3. customThe residue was chromatographed on silica gel (10:10:1:1 EtOAc/EtOH/NH4OH/H2O)