Sodium hydride → 9-[(2,4-Diaminofuro[2,3-d]pyrimidin-5-yl)methyl]-9,10-dihydrodibenz-[b,f]azepine

Participants

Role	Name	HCID	Charge
Reactant	Sodium hydride	HCID 24758	—
Reactant	n-[(2,4-Diaminofuro[2,3-d]pyrimidin-5-yl)methyl]-n,n-diphenylamine	HCID 9818937	—
Reactant	5-(Chloromethyl)furo[2,3-d]pyrimidine-2,4-diamine	HCID 11412959	—
Reactant	9,10-Dihydrodibenz[b,f]azepine	HCID 69591429	—
Product	9-[(2,4-Diaminofuro[2,3-d]pyrimidin-5-yl)methyl]-9,10-dihydrodibenz-[b,f]azepine	HCID 69591422	—

Reaction Steps

9-[(2,4-Diaminofuro[2,3-d]pyrimidin-5-yl)methyl]-9,10-dihydrodibenz-[b,f]azepine (Formula I: Ar=2,4-diaminofuro[2,3-d]pyrimidin-5-yl; W=CH2; X=N; Z=CH2CH2; m=n=0) is prepared similarly to N-[(2,4-diaminofuro[2,3-d]pyrimidin-5-yl)methyl]-N,N-diphenylamine as disclosed above by using 9,10-dihydrodibenz[b,f]azepine (158 mg, 0.8 mmol), sodium hydride (50 mg, 2.1 mmol), and 2,4-diamino-5-chloromethylfuro[2,3-d]pyrimidine (60 mg, 0.3 mmol). The product can be purified by chromatography.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07056911B1
Source dataset	uspto-grants-2006_06
ORD ID	ord-5039a483998643b280d03a40c0d10ea5
Source note	uspto-grants-2006_06