Sodium hydride → 9-[(2,4-Diaminofuro[2,3-d]pyrimidin-5-yl)methyl]-9,10-dihydrodibenz-[b,f]azepine

HRID 1827719ノート

反応式

HRID 1827719 の反応式
[NH2:1][C:2]1[N:3]=[C:4]([NH2:25])[C:5]2[C:10]([CH2:11]N(C3C=CC=CC=3)C3C=CC=CC=3)=[CH:9][O:8][C:6]=2[N:7]=1.[CH:26]1[C:36]2[C:30](=[N:31][C:32]3[CH:40]=[CH:39][CH2:38][CH2:37][C:33]=3[CH2:34][CH:35]=2)[CH:29]=[CH:28][CH:27]=1.[H-].[Na+].NC1N=C(N)C2C(CCl)=COC=2N=1>>[NH2:1][C:2]1[N:3]=[C:4]([NH2:25])[C:5]2[C:10]([CH2:11][CH:37]3[C:33]4[CH2:34][CH:35]=[C:36]5[CH:26]=[CH:27][CH:28]=[CH:29][C:30]5=[N:31][C:32]=4[CH:40]=[CH:39][CH2:38]3)=[CH:9][O:8][C:6]=2[N:7]=1

参加物

5

反応物 4

HCID 24758Sodium hydrideHCID 9818937n-[(2,4-Diaminofuro[2,3-d]pyrimidin-5-yl)methyl]-n,n-diphenylamineHCID 114129595-(Chloromethyl)furo[2,3-d]pyrimidine-2,4-diamineHCID 695914299,10-Dihydrodibenz[b,f]azepine

生成物 1

HCID 695914229-[(2,4-Diaminofuro[2,3-d]pyrimidin-5-yl)methyl]-9,10-dihydrodibenz-[b,f]azepine

実験手順

9-[(2,4-Diaminofuro[2,3-d]pyrimidin-5-yl)methyl]-9,10-dihydrodibenz-[b,f]azepine (Formula I: Ar=2,4-diaminofuro[2,3-d]pyrimidin-5-yl; W=CH2; X=N; Z=CH2CH2; m=n=0) is prepared similarly to N-[(2,4-diaminofuro[2,3-d]pyrimidin-5-yl)methyl]-N,N-diphenylamine as disclosed above by using 9,10-dihydrodibenz[b,f]azepine (158 mg, 0.8 mmol), sodium hydride (50 mg, 2.1 mmol), and 2,4-diamino-5-chloromethylfuro[2,3-d]pyrimidine (60 mg, 0.3 mmol). The product can be purified by chromatography.

後処理

  1. customThe product can be purified by chromatography

出典と根拠

ORDレコード
ord-5039a483998643b280d03a40c0d10ea5
出典データセット
uspto-grants-2006_06
特許番号
US07056911B1

反応ノート

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