Benzhydrylamine → HCID 22062977, compound

HRID 1827728Notes

Reaction equation

HRID 1827728 reaction equation
[CH:1]([NH2:14])([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH2:15][C:16]1[N:21]=[C:20]([NH2:22])[C:19]([CH2:23]N)=[CH:18][N:17]=1.CCN(CC)CC>>[NH2:15][C:16]1[N:21]=[C:20]([NH2:22])[C:19]([CH2:23][NH:14][CH:1]([C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=2)[C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)=[CH:18][N:17]=1

Participants

4

Reactant 3

HCID 7036Benzhydrylamine2×HCID 8471TriethylamineHCID 227659HCID 227659, compound

Product 1

HCID 22062977HCID 22062977, compound

Procedure

W=CH2NH; X=CH; Z=non-linked hydrogens on each phenyl group; m=n=0) is prepared similarly to N-(2,4-diaminopyrido[2,3-d]pyrimidin-6-yl)amino]benzhydrylamine as disclosed above by using benzhydrylamine (366 mg, 2.0 mmol), 2,4-diamino-5-aminomethylpyrimidine (278 mg, 2.0 mmol), mg, 2 mmol), and BH3.Et3N (75 mg, 6.6 mmol). The product can be purified by chromatography.

Workup

  1. customThe product can be purified by chromatography

Sources & evidence

ORD record
ord-98e7b32b829a439b8a558526adb6ec30
Source dataset
uspto-grants-2006_06
Patent number
US07056911B1

Reaction notes

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