Benzhydrylamine → HCID 22063012, compound

HRID 1827729Notes

Reaction equation

[CH:1]([NH2:14])([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C1(=O)C2C(C3C(C=2)=CC=CC=3)=CC=C1.[NH2:29][C:30]1[N:31]=[C:32]([NH2:41])[C:33]2[CH:39]=[C:38](N)[CH:37]=[N:36][C:34]=2[N:35]=1.CCN(CC)CC>>[NH2:29][C:30]1[N:31]=[C:32]([NH2:41])[C:33]2[CH:39]=[C:38]([NH:14][CH:1]3[C:8]4[CH:9]=[CH:10][CH:11]=[CH:12][C:13]=4[C:7]4[C:2]3=[CH:3][CH:4]=[CH:5][CH:6]=4)[CH:37]=[N:36][C:34]=2[N:35]=1

Participants

Reactant 4

HCID 7036Benzhydrylamine

HCID 8471Triethylamine

HCID 10821153HCID 10821153, compound

HCID 22281833Fluoreneone

Product 1

HCID 22063012HCID 22063012, compound

Procedure

9-[N-(2,4-Diaminopyrido[2,3-d]pyrimidin-6-yl)amino]fluorene (Formula I: Ar=2,4-diaminopyrido[2,3-d]pyrimidin-6-yl; W=NH; X=CH; Z=chemical bond; m=n=0) is prepared similarly to N-(2,4-diaminopyrido[2,3-d]pyrimidin-6-yl)amino]benzhydrylamine as disclosed above by using fluorenone (360 mg, 2.0 mmol), 2,4,6-triaminopyrido[2,3-d]pyrimidine (350 mmol), mg, 2.0 mmol), and BH3.Et3N (75 mg, 6.6 mmol). The product can be purified by chromatography.

Workup

customThe product can be purified by chromatography

Sources & evidence

ORD record: ord-03a56f4d7bb340e5a9770351093155e5
Source dataset: uspto-grants-2006_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07056911B1

Reaction notes

Loading…