Fluorene → HCID 481463, compound

Participants

Reaction Steps

5-[N-(2,4-Diaminoquinazolin-6-yl)amino]-5H-dibenzo[a,d]cycloheptene (Formula I: Ar=2,4-diaminoquinazolin-6-yl; W=NH; X=CH; Z=CH═CH; m=n=0) is prepared similarly to N-(2,4-diaminopyrido[2,3-d]pyrimidin-6-yl)amino]fluorene as disclosed above by using 5H-dibenzo[a,d]cycloheptan-5-one (412 mg, 2.0 mmol), 2,4,6-triaminoquinazoline (350 mg, 2.0 mmol), and BH3.Et3N (75 mg, 6.6 mmol). The product can be purified by chromatography.

Provenance & Evidence