Fluorene → HCID 481463, compound

HRID 1827731Notes

Reaction equation

HRID 1827731 reaction equation
[CH:1]1[C:13]2[CH2:12][C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[C:5]=2[CH:4]=[CH:3][CH:2]=1.[NH2:14][C:15]1[N:24]=[C:23]([NH2:25])[C:22]2[C:17](=[CH:18][CH:19]=[C:20]([NH2:26])[CH:21]=2)[N:16]=1.CCN([CH2:32][CH3:33])CC>>[NH2:14][C:15]1[N:24]=[C:23]([NH2:25])[C:22]2[C:17](=[CH:18][CH:19]=[C:20]([NH:26][CH:12]3[C:13]4[CH:1]=[CH:2][CH:3]=[CH:4][C:5]=4[CH:6]=[CH:7][C:8]4[CH:9]=[CH:10][CH:11]=[CH:32][C:33]3=4)[CH:21]=2)[N:16]=1

Participants

4

Reactant 3

HCID 6853FluoreneHCID 8471TriethylamineHCID 2926612,4,6-Triaminoquinazoline

Product 1

HCID 481463HCID 481463, compound

Procedure

5-[N-(2,4-Diaminoquinazolin-6-yl)amino]-5H-dibenzo[a,d]cycloheptene (Formula I: Ar=2,4-diaminoquinazolin-6-yl; W=NH; X=CH; Z=CH═CH; m=n=0) is prepared similarly to N-(2,4-diaminopyrido[2,3-d]pyrimidin-6-yl)amino]fluorene as disclosed above by using 5H-dibenzo[a,d]cycloheptan-5-one (412 mg, 2.0 mmol), 2,4,6-triaminoquinazoline (350 mg, 2.0 mmol), and BH3.Et3N (75 mg, 6.6 mmol). The product can be purified by chromatography.

Workup

  1. customThe product can be purified by chromatography

Sources & evidence

ORD record
ord-29f683ab79194e83a6f88d3cb8768484
Source dataset
uspto-grants-2006_06
Patent number
US07056911B1

Reaction notes

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