HCID 135724426, compound → HCID 135487799, compound

HRID 1827732Notes

Reaction equation

HRID 1827732 reaction equation
O.[N:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[NH:9][C:10]2[C:16]3[CH:17]=[CH:18][CH:19]=[CH:20][C:15]=3[N:14]([C:21]([C:23]3[CH:28]=[CH:27][C:26]([NH:29][C:30]([C:32]4[C:33]([C:38]5[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=5)=[CH:34][CH:35]=[CH:36][CH:37]=4)=[O:31])=[CH:25][CH:24]=3)=[O:22])[CH2:13][CH2:12][C:11]=2[N:44]=1>C(#N)C>[N:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[NH:9][C:10]2[C:16]3[CH:17]=[CH:18][CH:19]=[CH:20][C:15]=3[N:14]([C:21]([C:23]3[CH:28]=[CH:27][C:26]([NH:29][C:30]([C:32]4[C:33]([C:38]5[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=5)=[CH:34][CH:35]=[CH:36][CH:37]=4)=[O:31])=[CH:25][CH:24]=3)=[O:22])[CH2:13][CH2:12][C:11]=2[N:44]=1

Participants

3

Reactant 1

HCID 135724426HCID 135724426, compound

Product 1

HCID 135487799HCID 135487799, compoundYield 87.7%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Conditions

Temperature
95 °C

Procedure

To 1.0 g of the compound of Example 5 was added 20 mL of acetonitrile, and the mixture was stirred upon heating on an oil bath at 95° C. for 35 minutes. The suspension was cooled to room temperature, and a precipitate was collected by filtration and rinsed with 6 mL of acetonitrile to obtain 0.85 g of the titled compound.

Workup

  1. temperatureThe suspension was cooled to room temperature
  2. filtrationa precipitate was collected by filtration
  3. washrinsed with 6 mL of acetonitrile

Sources & evidence

ORD record
ord-6c6b78eefd35497cb751689d0a207a77
Source dataset
uspto-grants-2006_06
Patent number
US07056910B2

Reaction notes

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