Sodium Carbonate → Methyl benzimidate

HRID 1827842노트

반응식

HRID 1827842 반응식
Cl.[CH3:2][O:3][C:4](=[NH:11])[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1.C(=O)([O-])[O-].[Na+].[Na+]>C(OCC)C>[CH3:2][O:3][C:4](=[NH:11])[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1

참가 물질

4

반응물 2

HCID 10340Sodium CarbonateHCID 5743287Methyl benzimidate hydrochloride

생성물 1

HCID 345018Methyl benzimidate수율 81.4%

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

Benzimidic acid methyl ester hydrochloride (5 g, 29.1 mmol) was partitioned between saturated sodium carbonate solution (200 mL) and diethyl ether (100 mL). The organic layer was dried (MgSO4) and concentrated to provide the desired product as a colorless liquid (3.20 g, 81%). This material was used without further purification. 1H NMR (400 MHz, CDCl3) δ 3.93 (s, 3H), 7.39–7.46 (m, 3H), 7.75 (d, J=1.1 Hz, 2H).

후처리

  1. dry with materialThe organic layer was dried (MgSO4)
  2. concentrationconcentrated

출처 및 근거

ORD 기록
ord-e5204b29a4354152b23d144db8a2d913
출처 데이터셋
uspto-grants-2006_06
특허 번호
US07056915B2

반응 노트

불러오는 중…