HCID 11016234, compound → HCID 10310609, compound

HRID 1827902Notes

Reaction equation

HRID 1827902 reaction equation
[C:1]([O:6][C@H:7]1[C:24]([CH3:26])([CH3:25])[O:23][C:22]2[C:9](=[C:10]3[C:19](=[C:20]([O:27][CH3:28])[CH:21]=2)[C:18](=[O:29])[C:17]2[CH:16]=[C:15]4[CH:30]=[CH:31][CH:32]=[CH:33][C:14]4=[CH:13][C:12]=2[N:11]3[CH3:34])[C@H:8]1O)(=[O:5])[CH2:2][CH2:3][CH3:4]>ClCCl.Cl>[C:1]([O:6][C:7]1[C:24]([CH3:25])([CH3:26])[O:23][C:22]2[C:9](=[C:10]3[C:19](=[C:20]([O:27][CH3:28])[CH:21]=2)[C:18](=[O:29])[C:17]2[CH:16]=[C:15]4[CH:30]=[CH:31][CH:32]=[CH:33][C:14]4=[CH:13][C:12]=2[N:11]3[CH3:34])[CH:8]=1)(=[O:5])[CH2:2][CH2:3][CH3:4]

Participants

4

Reactant 1

HCID 11016234HCID 11016234, compound

Product 1

HCID 10310609HCID 10310609, compound

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidCatalystHCID 6344DichloromethaneSolvent

Procedure

To a solution of 0.29 mmol of the compound obtained in Step 1 in 6 ml of dichloromethane there are added 4 drops of 10% HCl solution. The reaction mixture is stirred at ambient temperature for 3 days and is then dried and evaporated under reduced pressure. Chromatography of the residue over silica gel (dichloromethane/methanol: gradient from 0.2 to 5%) allows the expected product to be isolated.

Workup

  1. customis then dried
  2. customevaporated under reduced pressure
  3. customto be isolated

Sources & evidence

ORD record
ord-d2d4de14ee6747aa8726e07e901b5c54
Source dataset
uspto-grants-2006_06
Patent number
US07056929B2

Reaction notes

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