Ethoxy-(3-pyridin-4-yl-pyrazol-1-yl)-acetic acid → (RS)-[amino-(4-{[2-ethoxy-2-(3-pyridin-4-yl-pyrazol-1-yl)-acetylamino]-methyl}-phenyl)-methylene]-carbamic acid benzyl ester

HRID 1828080Notes

Reaction equation

HRID 1828080 reaction equation
[CH2:1]([O:3][CH:4]([N:8]1[CH:12]=[CH:11][C:10]([C:13]2[CH:18]=[CH:17][N:16]=[CH:15][CH:14]=2)=[N:9]1)[C:5]([OH:7])=O)[CH3:2].Cl.Cl.[CH2:21]([O:28][C:29](=[O:41])[NH:30][C:31]([C:33]1[CH:38]=[CH:37][C:36]([CH2:39][NH2:40])=[CH:35][CH:34]=1)=[NH:32])[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1>>[CH2:21]([O:28][C:29](=[O:41])[N:30]=[C:31]([NH2:32])[C:33]1[CH:34]=[CH:35][C:36]([CH2:39][NH:40][C:5](=[O:7])[CH:4]([O:3][CH2:1][CH3:2])[N:8]2[CH:12]=[CH:11][C:10]([C:13]3[CH:18]=[CH:17][N:16]=[CH:15][CH:14]=3)=[N:9]2)=[CH:37][CH:38]=1)[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1

Participants

3

Reactant 2

HCID 22064729Ethoxy-(3-pyridin-4-yl-pyrazol-1-yl)-acetic acidHCID 141089245Carbamic acid, [[4-(aminomethyl)phenyl]iminomethyl]-, phenylmethyl ester, dihydrochloride

Product 1

HCID 69641596(RS)-[amino-(4-{[2-ethoxy-2-(3-pyridin-4-yl-pyrazol-1-yl)-acetylamino]-methyl}-phenyl)-methylene]-carbamic acid benzyl ester

Procedure

According to general method C, ethoxy-(3-pyridin-4-yl-pyrazol-1-yl)-acetic acid was reacted with [(4-aminomethyl-phenyl)-imino-methyl]-carbamic acid benzyl ester dihydrochloride (CAS 172348-75-3) to give (RS)-[amino-(4-{[2-ethoxy-2-(3-pyridin-4-yl-pyrazol-1-yl)-acetylamino]-methyl}-phenyl)-methylene]-carbamic acid benzyl ester. White powder. MS 513.3 ([M+H]+)

Sources & evidence

ORD record
ord-efb9188e3b84471bb7dd776cda3e732f
Source dataset
uspto-grants-2006_06
Patent number
US07056932B2

Reaction notes

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