HRID1828091

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：COC(C(=O)O)c1nc2ccccc2n1COCC[Si](C)(C)C

HCID22064658

未命名化合物

结构：Cl.Cl.N=C(NC(=O)OCc1ccccc1)c1ccc(CN)cc1

HCID141089245

Carbamic acid, [[4-(aminomethyl)phenyl]iminomethyl]-, phenylmethyl ester, dihydrochloride

C16H19Cl2N3O2

PRODUCTS

生成物

$结构：COC(C(=O)NCc1ccc(/C(N)=N\C(=O)OCc2ccccc2)cc1)c1nc2ccccc2n1COCC[Si](C)(C)C$

HCID178496437

未命名化合物

PROCEDURE

实验过程

According to general procedure C, (RS)-methoxy-[1-(2-trimethylsilanyl-ethoxymethyl)-1H-benzoimidazol-2-yl]-acetic acid was reacted with [(4-aminomethyl-phenyl)-imino-methyl]-carbamic acid benzyl ester dihydrochloride (CAS 172348-75-3) to give (RS)-[1-amino-1-[4-({2-methoxy-2-[1-(2-trimethylsilanyl-ethoxymethyl)-1H-benzoimidazol-2-yl]-acetylamino}-methyl)-phenyl]-meth-(E)-ylidene]-carbamic acid benzyl ester. Light yellow solid. MS 602.3 ([M+H]+)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-3bde4960113b48338554c33031cbb908
来源数据集: uspto-grants-2006_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07056932B2
来源说明: uspto-grants-2006_06

反应 SMILES

[CH3:1][O:2][CH:3]([C:7]1[N:11]([CH2:12][O:13][CH2:14][CH2:15][Si:16]([CH3:19])([CH3:18])[CH3:17])[C:10]2[CH:20]=[CH:21][CH:22]=[CH:23][C:9]=2[N:8]=1)[C:4](O)=[O:5].Cl.Cl.[CH2:26]([O:33][C:34](=[O:46])[NH:35][C:36]([C:38]1[CH:43]=[CH:42][C:41]([CH2:44][NH2:45])=[CH:40][CH:39]=1)=[NH:37])[C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1>>[CH2:26]([O:33][C:34](=[O:46])/[N:35]=[C:36](/[NH2:37])\[C:38]1[CH:39]=[CH:40][C:41]([CH2:44][NH:45][C:4](=[O:5])[CH:3]([O:2][CH3:1])[C:7]2[N:11]([CH2:12][O:13][CH2:14][CH2:15][Si:16]([CH3:19])([CH3:18])[CH3:17])[C:10]3[CH:20]=[CH:21][CH:22]=[CH:23][C:9]=3[N:8]=2)=[CH:42][CH:43]=1)[C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1