Ammonium Hydroxide → HCID 22063930, compound

HRID 1828171Notes

Reaction equation

HRID 1828171 reaction equation
[CH2:1]([N:5]1[C:9]2[CH:10]=[CH:11][C:12]([C:14]3[NH:15][C:16]([C:26](F)(F)F)=[N:17][C:18]=3[C:19]3[CH:20]=[C:21]([CH3:25])[CH:22]=[CH:23][CH:24]=3)=[CH:13][C:8]=2[N:7]([CH3:30])[C:6]1=[O:31])[CH:2]([CH3:4])[CH3:3].[OH-].[NH4+:33]>>[CH2:1]([N:5]1[C:9]2[CH:10]=[CH:11][C:12]([C:14]3[NH:15][C:16]([C:26]#[N:33])=[N:17][C:18]=3[C:19]3[CH:20]=[C:21]([CH3:25])[CH:22]=[CH:23][CH:24]=3)=[CH:13][C:8]=2[N:7]([CH3:30])[C:6]1=[O:31])[CH:2]([CH3:4])[CH3:3]

Participants

3

Reactant 2

HCID 14923Ammonium HydroxideHCID 22063848HCID 22063848, compound

Product 1

HCID 22063930HCID 22063930, compound

Procedure

1-Isobutyl-3-methyl-5-(5-m-tolyl-2-trifluoromethyl-3H-imidazol-4-yl)-1,3-dihydro-benzoimidazol-2-one (prepared as described previously using the method described for example 63 and Lombardino, J. G.; Wiseman, E. H. J. Med. Chem. 1974, 17(11), 1182–1188, 20 mg, 0.05 mmol) was suspended in 5% aqueous ammonium hydroxide solution (4.7 mL). The suspension was stirred for 5 days, after which time the reaction was concentrated in vacuo. The resulting material was purified by LC (Waters Symmetry C8, acetonitrile/water 40% to 100%) to afford 8 mg of the title compound as a white solid. MS (M+1)=386.2

Workup

  1. concentrationafter which time the reaction was concentrated in vacuo
  2. customThe resulting material was purified by LC (Waters Symmetry C8, acetonitrile/water 40% to 100%)

Sources & evidence

ORD record
ord-25fe9f646ac0418f9c94f59d7b05cd66
Source dataset
uspto-grants-2006_06
Patent number
US07056918B2

Reaction notes

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