Sulfuric acid hydrate (1:1) → HCID 22063879, compound

HRID 1828191Notes

Reaction equation

HRID 1828191 reaction equation
[CH:1]1([N:5]2[C:9]3[CH:10]=[CH:11][C:12]([CH2:14][C:15]#N)=[CH:13][C:8]=3[N:7]([CH3:17])[C:6]2=[O:18])[CH2:4][CH2:3][CH2:2]1.S(=O)(=O)(O)[OH:20].[OH2:24]>>[CH:1]1([N:5]2[C:9]3[CH:10]=[CH:11][C:12]([CH2:14][C:15]([OH:20])=[O:24])=[CH:13][C:8]=3[N:7]([CH3:17])[C:6]2=[O:18])[CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 21910475Sulfuric acid hydrate (1:1)HCID 22063940HCID 22063940, compound

Product 1

HCID 22063879HCID 22063879, compound

Conditions

Temperature
110 °C

Procedure

(1-Cyclobutyl-3-methyl-2-oxo-2,3-dihydro-1H-benzoimidazol-5-yl)-acetonitrile (11.5 g) was diluted with sulfuric acid:water (1:1, 25 mL) and was heated to 110° C. for 4 hour then cooled and extracted into ethyl acetate, dried over sodium sulfate and concentrated to give 11.99 g of (1-Cyclobutyl-3-methyl-2-oxo-2,3-dihydro-1H-benzoimidazol-5-yl)-acetic acid.

Workup

  1. temperaturethen cooled
  2. extractionextracted into ethyl acetate
  3. dry with materialdried over sodium sulfate
  4. concentrationconcentrated

Sources & evidence

ORD record
ord-ad8d7748c134485883e7398bd5961c35
Source dataset
uspto-grants-2006_06
Patent number
US07056918B2

Reaction notes

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