HCID 23581783, compound → HCID 22063995, compound

HRID 1828200Notes

Reaction equation

HRID 1828200 reaction equation
C([O:5][C:6](=[O:34])[CH2:7][N:8]1[CH:12]=[C:11]([C:13]2[CH:26]=[CH:25][C:16]3[N:17]([CH2:23][CH3:24])[C:18](=[O:22])[N:19]([CH2:20][CH3:21])[C:15]=3[CH:14]=2)[C:10]([C:27]2[CH:28]=[C:29]([CH3:33])[CH:30]=[CH:31][CH:32]=2)=[N:9]1)(C)(C)C>ClCCl.FC(F)(F)C(O)=O>[CH2:23]([N:17]1[C:16]2[CH:25]=[CH:26][C:13]([C:11]3[C:10]([C:27]4[CH:28]=[C:29]([CH3:33])[CH:30]=[CH:31][CH:32]=4)=[N:9][N:8]([CH2:7][C:6]([OH:34])=[O:5])[CH:12]=3)=[CH:14][C:15]=2[N:19]([CH2:20][CH3:21])[C:18]1=[O:22])[CH3:24]

Participants

4

Reactant 1

HCID 23581783HCID 23581783, compound

Product 1

HCID 22063995HCID 22063995, compoundYield 99.9%

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 6422Trifluoroacetic acidSolvent

Conditions

Temperature
23 °C

Procedure

[4-(1,3-Diethyl-2-oxo-2,3-dihydro-1H-benzoimidazol-5-yl)-3-m-tolyl-pyrazol-1-yl]-acetic acid tert-butyl ester (0.122 g) was diluted with dichloromethane (1 mL) and trifluoroacetic acid (0.5 mL). Upon stirring for 18 hours at 23° C. the mixture was concentrated to give [4-(1,3-Diethyl-2-oxo-2,3-dihydro-1H-benzoimidazol-5-yl)-3-m-tolyl-pyrazol-1-yl]-acetic acid (0.107 g).

Workup

  1. concentrationwas concentrated

Sources & evidence

ORD record
ord-afbf15651c054ad899ae26887132e536
Source dataset
uspto-grants-2006_06
Patent number
US07056918B2

Reaction notes

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