1-(2-Pyridyl)piperazine → HCID 10088837, compound

HRID 1828267Notes

Reaction equation

HRID 1828267 reaction equation
Br[CH2:2][C:3]1[C:7]2[CH:8]=[C:9]([Cl:12])[CH:10]=[CH:11][C:6]=2[S:5][CH:4]=1.[N:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[N:19]1[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]1>>[Cl:12][C:9]1[CH:10]=[CH:11][C:6]2[S:5][CH:4]=[C:3]([CH2:2][N:22]3[CH2:23][CH2:24][N:19]([C:14]4[CH:15]=[CH:16][CH:17]=[CH:18][N:13]=4)[CH2:20][CH2:21]3)[C:7]=2[CH:8]=1

Participants

3

Reactant 2

HCID 944591-(2-Pyridyl)piperazineHCID 27798573-(Bromomethyl)-5-chloro-1-benzothiophene

Product 1

HCID 10088837HCID 10088837, compound

Procedure

3-(Bromomethyl)-5-chloro-1-benzothiophene and 1-(2-pyridinyl)piperazine were processed as described in Example 2 to provide the title compound. 1H NMR (d6-DMSO, 300 MHz) δ 3.15 (m, 2H), 3.49 (m, 6H), 3.75 (s, 2H), 6.61 (dd, 1H, J=7.5, 4.5 Hz), 6.80 (d, 1H, J=8.7 Hz), 7.40 (dd, 1H, J=8.7, 1.5), 7.52 (m, 1H), 7.70 (s, 1H), 8.00 (d, 1H, J=8.7 Hz), 8.08 (m, 2H). MS (DCI/NH3) m/z 344.0 (M+H)+. Anal. Calcd for C18H18N3SCl: C, 62.87; H, 5.28; N, 12.22. Found: C, 62.71; H, 5.23; N, 12.26.

Sources & evidence

ORD record
ord-22a8dc78a4fb4669a95e5d7cdfe7a186
Source dataset
uspto-grants-2006_06
Patent number
US07057042B2

Reaction notes

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