1-(2-Methoxyphenyl)piperazine → HCID 10358835, compound

HRID 1828293Notes

Reaction equation

HRID 1828293 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[N:9]1[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]1.C(O[BH-](O[C:25](=[O:27])[CH3:26])OC(=O)C)(=O)C.[Na+]>>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[N:9]1[CH2:14][CH2:13][N:12]([CH2:7][C:6]2[O:27][C:25]3[C:26](=[N:9][CH:4]=[CH:3][CH:8]=3)[CH:5]=2)[CH2:11][CH2:10]1

Participants

3

Reactant 2

HCID 13461-(2-Methoxyphenyl)piperazineHCID 5049666Sodium triacetoxyborohydride

Product 1

HCID 10358835HCID 10358835, compound

Procedure

The product from Example 35B, 1-(2-methoxyphenyl)piperazine, and sodium triacetoxyborohydride were processed as described in Example 35C to provide the title compound. 1H NMR (CDCl3, 300 MHz) δ 2.85 (br, 4H), 3.19 (br, 4H), 3.85 (s, 3H), 3.88 (s, 2H), 6.93 (m, 5H), 7.20 (dd, 4.75, 8.14 Hz, 1H), 7.74 (m, J=1.02, 7.12 Hz, 1H), 8.54 (br, 1H); MS (DCI/NH3) m/z 324.2 (M+H)+; Anal Calcd for C19H21N3O2: C, 70.57; H, 6.55; N, 12.99. Found: C, 69.72; H, 6.45; N, 12.81.

Sources & evidence

ORD record
ord-9eda17b3be6f4a8e9b9f9d663e3e3969
Source dataset
uspto-grants-2006_06
Patent number
US07057042B2

Reaction notes

Loading…