反应详情

Ammonium picrate (0.92 g, 3.7 mmol) and ammonium carbamate (0.59 g, 7.5 mmol) are suspended in sulfolane (3 ml) and stirred for 2 hr with the temperature of the reaction increasing from 25° C. to 177° C. The reaction is continued an additional 6 hr at 177° C. and cooled to ambient temperature. Water (30 ml) is added to the slurry and the product is collected, washed with water and dried to yield 0.75 g (87%) of picramide (Table 1, entry 4).

1. temperatureincreasing from 25° C. to 177° C
2. waitThe reaction is continued an additional 6 hr at 177° C.
3. customthe product is collected
4. washwashed with water
5. customdried