Triphenylphosphine Oxide → HCID 86588093, compound

HRID 1828417Notes

Reaction equation

HRID 1828417 reaction equation
[CH:1]1([C:5]2[N:6]=[C:7]([CH2:10][CH2:11][C:12]3[CH:40]=[CH:39][N:15]4[C:16](=[O:38])[C:17](/[CH:29]=[CH:30]/[C:31]([O:33][C:34]([CH3:37])([CH3:36])[CH3:35])=[O:32])=[C:18]([N:20]5[CH2:25][CH2:24]C[CH:22]([O:26]C=O)[CH2:21]5)[N:19]=[C:14]4[CH:13]=3)[S:8][CH:9]=2)[CH2:4][CH2:3][CH2:2]1.C1(C2N=C(CCC3C=CN4C(=O)C(C=O)=C(N5CCOCC5)N=C4C=3)SC=2)CCC1.C1(P(=O)(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1>>[CH:1]1([C:5]2[N:6]=[C:7]([CH2:10][CH2:11][C:12]3[CH:40]=[CH:39][N:15]4[C:16](=[O:38])[C:17](/[CH:29]=[CH:30]/[C:31]([O:33][C:34]([CH3:37])([CH3:35])[CH3:36])=[O:32])=[C:18]([N:20]5[CH2:25][CH2:24][O:26][CH2:22][CH2:21]5)[N:19]=[C:14]4[CH:13]=3)[S:8][CH:9]=2)[CH2:4][CH2:3][CH2:2]1

Participants

4

Reactant 3

HCID 13097Triphenylphosphine OxideHCID 22063606HCID 22063606, compoundHCID 86588094HCID 86588094, compound

Product 1

HCID 86588093HCID 86588093, compoundYield 100%

Procedure

Reactions were performed in the same manner as in Example 1, (J) by using 8-[2-(4-cyclobutyl-1,3-thiazol-2-yl)ethyl]-2-morpholino-4-oxo-4H-pyrido[1,2-a]-pyrimidin-3-carbaldehyde (100 mg, 0.2356 mmol) to obtain 127 mg (100%) of the title compound as a yellow oily substance in a mixture with triphenylphosphine oxide.

Sources & evidence

ORD record
ord-106c6401ff314d439f2cb728c7bc0c59
Source dataset
uspto-grants-2006_06
Patent number
US07056917B2

Reaction notes

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