反应详情

温度

130 °C

N4-[4-(tert-Butyl)-1,3-thiazol-2-yl]-2-aminoisonicotinamide (200 mg, 0.724 mmol) was added with xylene (20 ml) and trichlorophenyl malonate (370 mg, 0.796 mmol) and refluxed by heating at 130° C. The reaction solution was stirred for 1 hour, then returned to room temperature and concentrated under reduced pressure. The resulting orange crystals was taken by filtration, washed with chloroform, dried under reduced pressure to obtain 209 mg (84%) of the title compound as orange crystals without purification.

1. temperaturerefluxed
2. customreturned to room temperature
3. concentrationconcentrated under reduced pressure
4. filtrationThe resulting orange crystals was taken by filtration
5. washwashed with chloroform
6. customdried under reduced pressure