1-Methylpiperazine → N8-(4-Cyclobutyl-1,3-thiazol-2-yl)-2-(4-methylpiperazino)-4-oxo-4H-pyrido[1,2-a]-pyrimidine-8-carboxamide

HRID 1828447Notes

Reaction equation

HRID 1828447 reaction equation
[CH:1]1([C:5]2[N:6]=[C:7]([NH:10][C:11]([C:13]3[CH:35]=[CH:34][N:16]4[C:17](=[O:33])[C:18](/C=C/C(O)=O)=[C:19]([N:21]5[CH2:26][CH2:25][N:24]([CH3:27])[CH2:23][CH2:22]5)[N:20]=[C:15]4[CH:14]=3)=[O:12])[S:8][CH:9]=2)[CH2:4][CH2:3][CH2:2]1.C1(C2N=C(NC(C3C=CN4C(=O)CC(=O)N=C4C=3)=O)SC=2)CCC1.CN1CCNCC1>>[CH:1]1([C:5]2[N:6]=[C:7]([NH:10][C:11]([C:13]3[CH:35]=[CH:34][N:16]4[C:17](=[O:33])[CH:18]=[C:19]([N:21]5[CH2:22][CH2:23][N:24]([CH3:27])[CH2:25][CH2:26]5)[N:20]=[C:15]4[CH:14]=3)=[O:12])[S:8][CH:9]=2)[CH2:4][CH2:3][CH2:2]1

Participants

4

Reactant 3

HCID 531671-MethylpiperazineHCID 22063612HCID 22063612, compoundHCID 22063633N8-(4-cyclobutyl-1,3-thiazol-2-yl)-2,4-dioxo-3,4-dihydro-2H-pyrido[1,2-a]pyrimidine-8-carboxamide

Product 1

HCID 22063628N8-(4-Cyclobutyl-1,3-thiazol-2-yl)-2-(4-methylpiperazino)-4-oxo-4H-pyrido[1,2-a]-pyrimidine-8-carboxamideYield 69%

Procedure

Reactions were performed in the same manner as in Example 8, (E) by using N8-(4-cyclobutyl-1,3-thiazol-2-yl)-2,4-dioxo-3,4-dihydro-2H-pyrido[1,2-a]pyrimidine-8-carboxamide (60 mg, 0.174 mmol) and N-methylpiperazine (60 μl, 1, 0.52 mmol) as regents to obtain 51.2 mg (69%) of the title compound.

Sources & evidence

ORD record
ord-2891a1d455b04a63a34b61d01c67a26a
Source dataset
uspto-grants-2006_06
Patent number
US07056917B2

Reaction notes

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