(E)-3-[8-{[(4-Cyclobutyl-1,3-thiazol-2-yl)amino]carbonyl}-2-(3-hydroxypiperidino)-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl]-2-propenoic acid → HCID 22063612, compound

HRID 1828448Notes

Reaction equation

HRID 1828448 reaction equation
C1(C2N=C(NC(C3C=CN4C(=O)C(/C=C/C(O)=O)=C(N5CCCC(O)C5)N=C4C=3)=O)SC=2)CCC1.[CH:36]1([C:40]2[N:41]=[C:42]([NH:45][C:46]([C:48]3[CH:71]=[CH:70][N:51]4[C:52](=[O:69])[C:53](/[CH:63]=[CH:64]/[C:65]([O:67]C)=[O:66])=[C:54]([N:56]5[CH2:61][CH2:60][N:59]([CH3:62])[CH2:58][CH2:57]5)[N:55]=[C:50]4[CH:49]=3)=[O:47])[S:43][CH:44]=2)[CH2:39][CH2:38][CH2:37]1>>[CH:36]1([C:40]2[N:41]=[C:42]([NH:45][C:46]([C:48]3[CH:71]=[CH:70][N:51]4[C:52](=[O:69])[C:53](/[CH:63]=[CH:64]/[C:65]([OH:67])=[O:66])=[C:54]([N:56]5[CH2:57][CH2:58][N:59]([CH3:62])[CH2:60][CH2:61]5)[N:55]=[C:50]4[CH:49]=3)=[O:47])[S:43][CH:44]=2)[CH2:39][CH2:38][CH2:37]1

Participants

3

Reactant 2

HCID 22063641(E)-3-[8-{[(4-Cyclobutyl-1,3-thiazol-2-yl)amino]carbonyl}-2-(3-hydroxypiperidino)-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl]-2-propenoic acidHCID 86588101HCID 86588101, compound

Product 1

HCID 22063612HCID 22063612, compoundYield 59%

Procedure

Reactions were performed in the same manner as in Example 7, (H) by using methyl (E)-3-[8-{[(4-cyclobutyl-1,3-thiazol-2-yl)amino]carbonyl}-2-(4-methylpiperazino)-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl]-2-propenoate (24.7 mg, 0.049 mmol) to obtain 14.1 mg (59%) of the title compound in yellow color.

Sources & evidence

ORD record
ord-63db049736df4d2aa5dfb3b712449f8a
Source dataset
uspto-grants-2006_06
Patent number
US07056917B2

Reaction notes

Loading…