Hydrogen Bromide → 2-Bromo-1-(pyridin-4-yl)ethanone

4-Acetylpyridine (3.62 g, 29.9 mmol) was added with acetic acid (30 ml) and 47% hydrobromic acid (5.3 ml) at room temperature, subsequently added dropwise with bromine (1.6 ml in total) four times at an interval of 5 minutes, stirred at room temperature for 2 hours and 30 minutes. The mixture was further added with bromine (1.6 ml), and stirred at room temperature for 20 hours. The reaction solution was filtered, and the resulting crystals were washed with diethyl ether and dried to obtain 12.43 g of the title compound as a salt of hydrogen bromide in the form of orange crystals without purification.

1. stirringstirred at room temperature for 20 hours
2. filtrationThe reaction solution was filtered
3. washthe resulting crystals were washed with diethyl ether
4. customdried

ORD record

ord-f675f5a41e374bab99154884b6223bf6

Source dataset

uspto-grants-2006_06

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07056917B2