HCID 22063527, compound → HCID 86588103, compound

HRID 1828457Notes

Reaction equation

HRID 1828457 reaction equation
[CH:1]([C:4]1[N:5]=[C:6]([NH:9][C:10]([C:12]2[CH:36]=[CH:35][N:15]3[C:16](=[O:34])[C:17]([C:20]4[N:21]=[N:22][N:23](CC5C=CC(OC)=CC=5)[N:24]=4)=[CH:18][N:19]=[C:14]3[CH:13]=2)=[O:11])[S:7][CH:8]=1)([CH3:3])[CH3:2]>FC(F)(F)C(O)=O>[CH:1]([C:4]1[N:5]=[C:6]([NH:9][C:10]([C:12]2[CH:36]=[CH:35][N:15]3[C:16](=[O:34])[C:17]([C:20]4[N:21]=[N:22][NH:23][N:24]=4)=[CH:18][N:19]=[C:14]3[CH:13]=2)=[O:11])[S:7][CH:8]=1)([CH3:3])[CH3:2]

Participants

3

Reactant 1

HCID 22063527HCID 22063527, compound

Product 1

HCID 86588103HCID 86588103, compound

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

N8-(4-Isopropyl-1,3-thiazol-2-yl)-3-[2-(4-methoxybenzyl)-2H-1,2,3,4-tetrazol-5-yl]-4-oxo-4H-pyrido[1,2-a]pyrimidine-8-carboxamide (330 mg, 0.66 mmol) was added with trifluoroacetic acid (10 ml) at room temperature and stirred for 3 days. The reaction solution was poured into ice water, and the deposited yellow crystals were collected by filtration, washed with water, then dissolved in chloroform and ethanol, and concentrated under reduced pressure. The resulting yellow crystals were suspended in a small amount of ethanol, and the crystals were taken by filtration and washed with diethyl ether to obtain 54 mg (21% for the two steps) of the title compound as yellow crystals.

Workup

  1. filtrationthe deposited yellow crystals were collected by filtration
  2. washwashed with water
  3. dissolutiondissolved in chloroform
  4. concentrationethanol, and concentrated under reduced pressure
  5. filtrationthe crystals were taken by filtration
  6. washwashed with diethyl ether

Sources & evidence

ORD record
ord-4fa3fe54d21146e89242125bbf89b130
Source dataset
uspto-grants-2006_06
Patent number
US07056917B2

Reaction notes

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