Thionyl Chloride → HCID 22063674, compound

HRID 1828473Notes

Reaction equation

HRID 1828473 reaction equation
[CH3:1][O:2][C:3]1[CH:18]=[CH:17][C:6]([CH2:7][N:8]2[N:12]=[N:11][C:10]([CH2:13][C:14](O)=[O:15])=[N:9]2)=[CH:5][CH:4]=1.S(Cl)([Cl:21])=O>>[CH3:1][O:2][C:3]1[CH:18]=[CH:17][C:6]([CH2:7][N:8]2[N:12]=[N:11][C:10]([CH2:13][C:14]([Cl:21])=[O:15])=[N:9]2)=[CH:5][CH:4]=1

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 22063596HCID 22063596, compound2×

Product 1

HCID 22063674HCID 22063674, compoundYield 96.4%

Procedure

The 2-[2-(4-methoxybenzyl)-2H-1,2,3,4-tetrazol-5-yl]acetic acid (262.0 mg, 1.05 mmol) obtained in (B) was added dropwise with thionyl chloride (615.9 μl, 8.44 mmol) under ice cooling and stirred at room temperature for 30 minutes. Excessive regents were evaporated to obtain the title compound (0.27 g, quantitative) as pale yellow oil.

Workup

  1. customExcessive regents were evaporated

Sources & evidence

ORD record
ord-08b46b59e2174ea58b9815c8042100ae
Source dataset
uspto-grants-2006_06
Patent number
US07056917B2

Reaction notes

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