HCID 69603267, compound → HCID 69603327, compound

HRID 1828475Notes

Reaction equation

HRID 1828475 reaction equation
[CH:1]([C:4]1[N:5]=[C:6]([CH2:9][CH2:10][C:11]2[CH:44]=[CH:43][N:14]3[C:15](=[O:42])[C:16]([C:25](=[O:41])[CH2:26][C:27]4[N:28]=[N:29][N:30](CC5C=CC(OC)=CC=5)[N:31]=4)=[C:17]([N:19]4[CH2:24][CH2:23][O:22][CH2:21][CH2:20]4)[N:18]=[C:13]3[CH:12]=2)[S:7][CH:8]=1)([CH3:3])[CH3:2]>FC(F)(F)C(O)=O>[CH:1]([C:4]1[N:5]=[C:6]([CH2:9][CH2:10][C:11]2[CH:44]=[CH:43][N:14]3[C:15](=[O:42])[C:16]([C:25](=[O:41])[CH2:26][C:27]4[N:28]=[N:29][NH:30][N:31]=4)=[C:17]([N:19]4[CH2:20][CH2:21][O:22][CH2:23][CH2:24]4)[N:18]=[C:13]3[CH:12]=2)[S:7][CH:8]=1)([CH3:3])[CH3:2]

Participants

3

Reactant 1

HCID 69603267HCID 69603267, compound2×

Product 1

HCID 69603327HCID 69603327, compoundYield 69.3%

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

The 8-[2-(4-isopropyl-1,3-thiazol-2-yl)ethyl]-3-{2-[2-(4-methoxybenzyl)-2H -1,2,3,4-tetrazol-5-yl]acetyl}-2-morpholino-4 H-pyrido[1,2-a]pyrimidin-4-one (8.9 mg, 0.014 mmol) obtained in (D) was dissolved in trifluoroacetic acid (5 ml)and stirred at room temperature for 18 hours. The solvent was evaporated, and the residue was purified by preparative TLC (chloroform:methanol=10:1, v/v) and lyophilized from dioxane to obtain the title compound (4.8 mg, 67.0%) as pale yellow powder.

Workup

  1. customThe solvent was evaporated
  2. customthe residue was purified by preparative TLC (chloroform

Sources & evidence

ORD record
ord-80110b2aeb3e4ddeb1188e159cb8e0ab
Source dataset
uspto-grants-2006_06
Patent number
US07056917B2

Reaction notes

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