HCID 86588114, compound → HCID 44362990, compound

HRID 1828480Notes

Reaction equation

HRID 1828480 reaction equation
[CH:1]([C:4]1[N:5]=[C:6]([CH2:9][CH2:10][C:11]2[CH:36]=[CH:35][N:14]3[C:15](=[O:34])[C:16](/[CH:25]=[CH:26]/[C:27]([O:29]C(C)(C)C)=[O:28])=[C:17]([N:19]4[CH2:24][CH2:23][O:22][CH2:21][CH2:20]4)[N:18]=[C:13]3[CH:12]=2)[S:7][CH:8]=1)([CH3:3])[CH3:2]>C(O)=O>[CH:1]([C:4]1[N:5]=[C:6]([CH2:9][CH2:10][C:11]2[CH:36]=[CH:35][N:14]3[C:15](=[O:34])[C:16](/[CH:25]=[CH:26]/[C:27]([OH:29])=[O:28])=[C:17]([N:19]4[CH2:24][CH2:23][O:22][CH2:21][CH2:20]4)[N:18]=[C:13]3[CH:12]=2)[S:7][CH:8]=1)([CH3:3])[CH3:2]

Participants

3

Reactant 1

HCID 86588114HCID 86588114, compound2×

Product 1

HCID 44362990HCID 44362990, compoundYield 86.4%

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

The tert-butyl (E)-3-{8-[2-(4-isopropyl-1,3-thiazol-2-yl)ethyl]-2-morpholino-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl}-2-propenoate (39 mg) obtained in (D) was stirred in formic acid (1 ml) for 4.5 hours, and the solvent was evaporated under reduced pressure to obtain the title compound (30 mg).

Workup

  1. customthe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-900ce00c151e4adb843cff86229b3fd2
Source dataset
uspto-grants-2006_06
Patent number
US07056917B2

Reaction notes

Loading…