HCID 22063609, compound → HCID 22063724, compound

HRID 1828483Notes

Reaction equation

HRID 1828483 reaction equation
[CH:1]([C:4]1[N:5]=[C:6]([CH2:9][CH2:10][C:11]2[CH:46]=[CH:45][N:14]3[C:15](=[O:44])[C:16](/[CH:25]=[CH:26]/[C:27]([NH:29][S:30]([CH2:33][CH2:34][CH2:35][NH:36]C(OC(C)(C)C)=O)(=[O:32])=[O:31])=[O:28])=[C:17]([N:19]4[CH2:24][CH2:23][O:22][CH2:21][CH2:20]4)[N:18]=[C:13]3[CH:12]=2)[S:7][CH:8]=1)([CH3:3])[CH3:2]>FC(F)(F)C(O)=O>[CH:1]([C:4]1[N:5]=[C:6]([CH2:9][CH2:10][C:11]2[CH:46]=[CH:45][N:14]3[C:15](=[O:44])[C:16](/[CH:25]=[CH:26]/[C:27]([NH:29][S:30]([CH2:33][CH2:34][CH2:35][NH2:36])(=[O:32])=[O:31])=[O:28])=[C:17]([N:19]4[CH2:20][CH2:21][O:22][CH2:23][CH2:24]4)[N:18]=[C:13]3[CH:12]=2)[S:7][CH:8]=1)([CH3:3])[CH3:2]

Participants

3

Reactant 1

HCID 22063609HCID 22063609, compound2×

Product 1

HCID 22063724HCID 22063724, compound

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

The N-((E)-3-{8-[2-(4-isopropyl-1,3-thiazol-2-yl)ethyl]-2-morpholino-4-oxo-4H-pyrido -[1,2-a]pyrimidin-3-yl}-2-propenoyl)-3-(tert-butoxycarbonylamino)-1-propane -sulfonamide (32 mg) obtained in (A) was dissolved in trifluoroacetic acid (2 ml) and stirred for 40 minutes. The solvent was evaporated under reduced pressure, and the residue was purified by medium pressure reverse phase column chromatography to obtain the title compound (quantitative).

Workup

  1. customThe solvent was evaporated under reduced pressure
  2. customthe residue was purified by medium pressure

Sources & evidence

ORD record
ord-972b2b934032461f93342fbc8d951992
Source dataset
uspto-grants-2006_06
Patent number
US07056917B2

Reaction notes

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