HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1828514Generated: November 1, 2026
Bromobenzene → ethyl (E)-3-{8-[2-(4-isopropyl-1,3-thiazol-2-yl)ethyl]-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl}-2-propenoate
https://huagongshe.com/reaction/1828514
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Bromobenzene | HCID 7961 | — |
| Reactant | 4-[2-(4-Isopropyl-1,3-thiazol-2-yl)ethyl]-2-aminopyridine | HCID 22063652 | — |
| Reactant | Diethyl 1-dimethylamino-1,3-butadiene-2,4-dicarboxylate | HCID 54366534 | — |
| Product | ethyl (E)-3-{8-[2-(4-isopropyl-1,3-thiazol-2-yl)ethyl]-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl}-2-propenoate | HCID 86588142 | 6.2% |
Reaction Steps
4-[2-(4-Isopropyl-1,3-thiazol-2-yl)ethyl]-2-aminopyridine(200 mg), diethyl 4-dimethylaminomethyleneglutaconate (265 mg) was added with bromobenzene (2 ml) and heated at 120° C. for 1 hour and at 160° C. for 4 hours with stirring. The residue was purified by silica gel column chromatography to obtain the title compound (20 mg) as white powder.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07056917B2 |
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| Source dataset | uspto-grants-2006_06 |
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| ORD ID | ord-8e1ee26a48b34949bd410e20598ecf71 |
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| Source note | uspto-grants-2006_06 |
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