3-Methoxy-4-methyl-2-nitropyridine → 2-Pyridinamine,3-methoxy-4-methyl-(9CI)

HRID 1828529Notes

Reaction equation

HRID 1828529 reaction equation
[CH3:1][O:2][C:3]1[C:4]([N+:10]([O-])=O)=[N:5][CH:6]=[CH:7][C:8]=1[CH3:9]>CO.[Pd]>[NH2:10][C:4]1[C:3]([O:2][CH3:1])=[C:8]([CH3:9])[CH:7]=[CH:6][N:5]=1

Participants

4

Reactant 1

HCID 149295773-Methoxy-4-methyl-2-nitropyridine2×

Product 1

HCID 220637652-Pyridinamine,3-methoxy-4-methyl-(9CI)Yield 103.4%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

The 3-methoxy-4-methyl-2-nitropyridine (1 g) obtained in (A) was dissolved in methanol (50 ml), added with 5% Pd/C (200 mg), and stirred at a pressure of 40 psi for 2 hours under hydrogen atmosphere. After the catalyst was removed by filtration, the solvent was evaporated under reduced pressure to obtain the title compound (850 mg) as yellow oil.

Workup

  1. customAfter the catalyst was removed by filtration
  2. customthe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-51b8d38c280b4a1b873c80a8120d7d35
Source dataset
uspto-grants-2006_06
Patent number
US07056917B2

Reaction notes

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