Octahydroindolizin-7-one → Octahydro-7-indolizinol

HRID 1828635Notes

Reaction equation

HRID 1828635 reaction equation
[N:1]12[CH2:9][CH2:8][CH2:7][CH:6]1[CH2:5][C:4](=[O:10])[CH2:3][CH2:2]2.[H-].[Al+3].[Li+].[H-].[H-].[H-]>O1CCCC1>[N:1]12[CH2:9][CH2:8][CH2:7][CH:6]1[CH2:5][CH:4]([OH:10])[CH2:3][CH2:2]2

Participants

4

Reactant 2

HCID 11240524Octahydroindolizin-7-oneHCID 21226445Aluminium lithium hydride

Product 1

HCID 22056626Octahydro-7-indolizinolYield 100%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

1-Azabicyclo[4,3,0]nonan-4-one (1.0 g, 0.0072 moles) (King, F. D., J. Chem. Soc. Perkin. Trans. 1, (1986) 447) in tetrahydrofuran (50 ml) was treated with lithium aluminium hydride (0.7 g. 0.0185 moles) at ambient temperature for 18 hours. Work up in the usual way gave the title compound 1.0 g (100%). M.S. (+ve ion electrospray) m/z 142 (MH30 , 95%).

Sources & evidence

ORD record
ord-4ebb1a420a6d4c77b3a443fb887f6a46
Source dataset
uspto-grants-2006_06
Patent number
USRE039128E1

Reaction notes

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