Sodium Hydroxide → HCID 21028574, compound

HRID 1828647Notes

Reaction equation

HRID 1828647 reaction equation
C(OC([C:8]1[S:12][C:11]2[CH:13]=[C:14]([OH:19])[C:15]([O:17][CH3:18])=[CH:16][C:10]=2[C:9]=1[OH:20])=O)CCC.[OH-].[Na+]>>[OH:20][C:9]1[C:10]2[CH:16]=[C:15]([O:17][CH3:18])[C:14]([OH:19])=[CH:13][C:11]=2[S:12][CH:8]=1

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 54717659HCID 54717659, compound

Product 1

HCID 21028574HCID 21028574, compoundYield 63%

Procedure

2.96 g (10 mmol) XVI and 6.00 g NaOH were heated under reflux for 3.5 h in 100 ml degassed water. The still hot solution was then acidified with concentrated HCl to pH 1. The compound XVII precipitating on cooling in an ice bath was removed and washed with a little n-hexane. A yield of 1.23 g XVII (6.3 mmol, 63%) was obtained.

Workup

  1. temperatureunder reflux for 3.5 h in 100 ml
  2. customdegassed water
  3. customThe compound XVII precipitating
  4. temperatureon cooling in an ice bath
  5. customwas removed
  6. washwashed with a little n-hexane

Sources & evidence

ORD record
ord-09b20814bcc84524a8353cfbe118963c
Source dataset
uspto-grants-2006_06
Patent number
US07060109B2

Reaction notes

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