反应详情

温度

0 °C

The product from step 2 was dissolved in dry CH2Cl2 and the solution was cooled to 0° C. Triethylamine (1.5 molar equiv) was added. After 10 min, trityl chloride (1.1 molar equiv) followed by DMAP (0.2 molar equiv) were added and stirred over night at room temperature. The reaction was then quenched with saturated NH4Cl solution, the organic layer was separated and the aqueous layer was extracted with EtOAc. The combined organic extracts were washed with water, brine, dried (Na2SO4) and concentrated in vacuo. Purification by column chromatography afforded (5S)-5-(trityloxymethyl)-2-oxo-tetrahydrofuran in 76% yield.

1. additionwere added
2. customThe reaction was then quenched with saturated NH4Cl solution
3. customthe organic layer was separated
4. extractionthe aqueous layer was extracted with EtOAc
5. washThe combined organic extracts were washed with water, brine
6. dry with materialdried (Na2SO4)
7. concentrationconcentrated in vacuo
8. customPurification by column chromatography